cPNI Masters module taught by Tom Fox covering the integration of nutritional science and movement physiology within the psychoneuroimmunological framework. Focuses on amino acids (especially leucine and lysine), muscle protein synthesis, mTOR signaling, exercise immunology, and practical clinical nutrition protocols.
Module explores how nutrients (particularly BCAAs, essential amino acids) and movement patterns trigger signaling cascades (mTOR, AMPK, PGC-1Ξ±) that regulate muscle protein synthesis, mitochondrial biogenesis, myokine production, and systemic metabolic health. Covers hormetic stressors, intermittent fasting, and the 27 lifestyle factors framework.
Provides cPNI practitioners with evidence-based approaches to prescribe nutrition and movement interventions that modulate inflammation, enhance metabolic flexibility, support muscle mass, and optimize systemic health. Critical for addressing sarcopenia, metabolic syndrome, chronic inflammation, and movement-related pain conditions.
- Leucine is primary mTOR activator for muscle protein synthesis
- Lysine indirectly supports mTOR by inhibiting mTOR inhibitors
- Exercise produces anti-inflammatory myokines (IL-6, IL-10, irisin)
- Sedentary behavior breaks critical for metabolic health
- Intermittent fasting enhances metabolic flexibility and autophagy
- Tom Fox teaches this module with Q&A and masterclass sessions
- Covers energy distribution metamodel and Hunter-Farmer phenotypes
- Integrates nutritional interventions with exercise prescription
- Tom Fox β lecturer for Module 10 on nutrition and movement
- leucine β key amino acid covered as primary mTOR activator
- lysine β amino acid covered for mTOR pathway modulation
- mTOR β central signaling pathway regulating muscle protein synthesis
- muscle protein synthesis β core physiological process regulated by nutrition
- myokines β exercise-induced signaling molecules with systemic effects
- intermittent fasting β nutritional intervention for metabolic flexibility
- exercise β movement modality with immunological and metabolic effects
- metabolic flexibility β capacity to switch fuel sources, enhanced by nutrition and movement
- sarcopenia β age-related muscle loss addressed through nutrition and exercise
- inflammation β exercise and nutrition modulate inflammatory status
- Hunter-Farmer phenotype β metabolic phenotypes influencing nutrition response
- energy distribution metamodel β framework for understanding metabolic allocation
- BCAAs β branched-chain amino acids critical for muscle anabolism
- sedentary behavior β movement deficit with metabolic consequences
- hormesis β beneficial adaptive response to exercise stress
- autophagy β cellular cleanup enhanced by fasting and exercise
- mitochondrial biogenesis β exercise-induced increase in mitochondrial mass
- PGC-1Ξ± β master regulator of mitochondrial biogenesis induced by exercise
- AMPK β energy sensor activated by exercise and fasting