Concepts bridging gastrointestinal function and immune defence -- barrier integrity, GALT, mucosal immunity, oral tolerance, and the leaky gut paradigm. The gut houses 70% of immune tissue, making this the largest immune-environmental interface in the body.
| Concept | Categories |
|---|---|
| 5-HT | molecule-mediator |
| A1 beta-casein | process |
| allergic rhinitis | clinical-concept |
| allergies | process |
| allicin | intervention |
| Alpha-gal mutation | process, environmental |
| Amphiregulin | molecule-mediator |
| AMPs | -- |
| AMY1 gene copy number | gene-protein |
| Amylase copies | gene-protein |
| Amylase-Trypsin-Inhibitor (ATI) | cell-type, process |
| Amylase-Trypsin-Inhibitor (ATI) | process |
| anemia | process |
| Antinutrients in Grains and Legumes | process |
| appendix | structure |
| aryl hydrocarbon receptor | receptor-channel, gene-protein |
| ataxia | -- |
| atopic dermatitis | clinical-concept |
| atopic march | clinical-concept |
| atopobiosis | process, organism, clinical-concept |
| Avenine | clinical-concept, nutrient |
| Avenine | uncategorized |
| B cells | cell-type |
| Bacillus subtilis | organism, clinical-concept, intervention |
| bacteria | organism |
| bacterial translocation | process, clinical-concept |
| bacteriocins | organism |
| baicalein | molecule-mediator |
| barrier damage | process |
| barrier dysfunction | process, cell-type, clinical-concept |
| beta-casein | clinical-concept, process |
| beta-glucuronidase | molecule-mediator, organism |
| Bifidobacteria | organism |
| Bifidobacterium | organism |
| Bifidobacterium infantis | organism |
| bile acid | organism |
| Bile acids | organism |
| Bovine Serum Albumin | nutrient |
| BSA | clinical-concept |
| Butyrate | molecule-mediator, process, intervention |
| Butyrophilin | clinical-concept |
| C5a | process |
| cadaverine | environmental |
| Calprotectin | diagnostic |
| Casein | uncategorized |
| CCL20 | uncategorized |
| CD14 | receptor-channel, cell-type |
| cilia | structure |
| citrullination and molecular mimicry | uncategorized |
| Clinical Example - Cystitis Treatment | clinical-example |
| Coeliac disease | clinical-concept |
| Coherence Disturbance | uncategorized |
| colitis | clinical-concept, process |
| collagen | process |
| colon | structure, organism |
| colon cancer | clinical-concept |
| Coriander | intervention, nutrient |
| COVID-19 | receptor-channel, intervention, psychological |
| COX | molecule-mediator, process |
| COX enzymes | molecule-mediator, process |
| COX-1 | molecule-mediator |
| Creeping fat | process, clinical-concept |
| Crohn's disease | clinical-concept |
| CXCL1 | process |
| CXCR3 | receptor-channel |
| CXCR3 receptor | receptor-channel |
| CYP enzyme | molecule-mediator, environmental |
| CYP1A1 | molecule-mediator, environmental |
| cystic fibrosis | process |
| cystitis | clinical-concept, intervention |
| DAMPs | cell-type, process |
| DAO enzyme | molecule-mediator |
| DCIR | receptor-channel |
| Dectin-1 | receptor-channel, cell-type |
| defensin | cell-type, organism |
| defensins | cell-type, organism |
| dendritic cells | cell-type |
| detoxification | process, nutrient, environmental |
| diet | intervention |
| dorsal motor nucleus of vagus | structure |
| DPP IV | molecule-mediator |
| DPP IV | molecule-mediator |
| dysbiosis | process, organism |
| eczema | clinical-concept, process |
| Endotoxaemia | process |
| Endotoxemia | organism, nutrient, environmental |
| endotoxins | organism, process |
| Enterobacter | organism |
| Enterobacteriaceae | organism |
| Enterococcus | organism |
| Enterococcus faecalis | organism |
| Enterococcus faecium | organism |
| enterocyte | structure, cell-type |
| enterocytes | structure, cell-type |
| Escherichia | organism |
| Escherichia coli | organism |
| Faecalibacterium prausnitzii | diagnostic, molecule-mediator, organism |
| fat malabsorption | clinical-concept, process |
| fatty liver | process, clinical-concept |
| Fatty Liver Disease | process, molecule-mediator, clinical-concept |
| food intolerances | uncategorized |
| food sensitivities | uncategorized |
| Fusobacterium | organism |
| GALT | cell-type |
| gastric ulcers | process, clinical-concept |
| gastrin | molecule-mediator |
| gastritis | clinical-concept, process |
| gastrointestinal tract | structure |
| Ginger | molecule-mediator |
| Gliadin | clinical-concept |
| Gliadin | process, clinical-concept |
| Glutamine | molecule-mediator |
| glutathione system | molecule-mediator, system-axis |
| Gluten | clinical-concept |
| gluten sensitivity | process, clinical-concept |
| Gluten toxicity | uncategorized |
| glycoproteins | uncategorized |
| glyphosate | environmental, clinical-concept |
| GMP-7 | receptor-channel, psychological |
| goblet cell | cell-type, nutrient, gene-protein |
| goblet cells | cell-type, nutrient, gene-protein |
| GPR35 | receptor-channel, organism |
| gut | structure |
| gut bacteria | organism |
| gut barrier | structure, cell-type, nutrient |
| gut barrier function | process, structure |
| gut barrier permeability | process |
| gut dysbiosis | process, organism |
| gut dysfunction | process, system-axis, nutrient |
| gut health | intervention, clinical-concept |
| gut microbiome | organism |
| gut microbiota | organism |
| gut mucosa | structure |
| gut permeability | organism, nutrient, environmental |
| gut-associated lymphoid tissue | cell-type, organism |
| gut-microbiome | organism |
| H. pylori | organism |
| Helicobacter pylori | organism |
| heme | uncategorized |
| heparin | intervention, environmental |
| hepatitis C | process, organism |
| hepatocytes | cell-type, nutrient, environmental |
| hydrochloric acid | molecule-mediator, organism |
| hydrogen peroxide | organism, intervention, gene-protein |
| hydrogen SIBO | clinical-concept, diagnostic |
| I3C | cell-type, intervention, nutrient |
| IBD | clinical-concept, process, organism |
| IBS | clinical-concept, process |
| IgA | organism |
| IL-10 | molecule-mediator |
| ileocecal valve | structure |
| ileum | structure |
| immune dysfunction | clinical-concept, process |
| immune tolerance | clinical-concept |
| inflammatory bowel disease | clinical-concept |
| Intestinal permeability | structure, process |
| Kafirin | clinical-concept |
| Klebsiella | organism |
| L-Arginine | molecule-mediator, intervention |
| Lactic acid | molecule-mediator |
| Lactobacillaceae | organism |
| Lactobacilli | organism, intervention |
| Lactobacillus | organism |
| Lactobacillus plantarum | clinical-concept, intervention, organism |
| Lactobacillus reuteri | organism |
| Lactobacillus spp. | organism |
| Lactoferricin | cell-type, organism |
| Lactoferrin | intervention, cell-type |
| Lactoperoxidase | molecule-mediator |
| lamina propria | structure |
| leaky gut | process |
| Leaky mouth | organism, clinical-concept, diagnostic |
| Lectins | process |
| lipase | molecule-mediator |
| lipopolysaccharide | process |
| Liver | structure |
| liver dysfunction | process |
| liver function | process, nutrient, environmental |
| LPS | cell-type, system-axis, organism |
| microbiome | organism |
| mucin | organism, structure |
| mucins | organism, structure |
| mucosal immunity | structure |
| mucus | structure |
| mucus layer | structure |
| mycotoxins | molecule-mediator, organism, historical |
| myeloperoxidase | molecule-mediator |
| Myosin light chain kinase | molecule-mediator |
| N-glycolylneuraminic acid | diagnostic, nutrient, environmental |
| NAFLD | clinical-concept, process |
| NASH | clinical-concept, process |
| Neu5Gc | process |
| nitrate | organism |
| nutrition | intervention |
| obligate anaerobes | organism |
| occludin | receptor-channel, nutrient, psychological |
| oligosaccharides | organism, nutrient, cell-type |
| Oral Barrier | structure, environmental |
| Oral dysbiosis | process, organism, clinical-concept |
| oral tolerance | intervention, organism |
| pancreatic enzymes | molecule-mediator |
| pancreatitis | process |
| Paneth cells | cell-type |
| PAR-2 | receptor-channel, structure, process |
| parasites | organism |
| Peanut Shell Agglutinin | receptor-channel, cell-type |
| Peyer's patches | intervention, organism |
| polysaccharides | nutrient |
| portal vein | structure |
| Postprandial immune response | environmental, process, nutrient |
| Prolamine | environmental |
| proteases | molecule-mediator, process |
| Protein-S | molecule-mediator, structure |
| RALDH2 | molecule-mediator |
| respiratory epithelium | structure |
| retinoic acid | receptor-channel |
| Ruminococcaceae | organism |
| Saccharomyces boulardii | intervention, organism, environmental |
| saliva | structure |
| salivary glycoproteins | structure |
| salivary IgA | diagnostic, psychological |
| Salmonella | organism |
| Salmonella | organism, nutrient |
| Saponins | clinical-concept, nutrient |
| SCFA | organism |
| SCFAs | molecule-mediator, organism |
| Secaline | clinical-concept |
| Secaline | uncategorized |
| secondary plant metabolites | nutrient, process |
| secretory component | structure |
| serrapeptase | molecule-mediator |
| short-chain fatty acid | molecule-mediator, organism |
| Short-chain fatty acids | molecule-mediator, organism |
| sialic acid | cell-type, nutrient |
| SIBO | clinical-concept |
| sIgA | organism |
| Silybum marianum | intervention |
| small intestine | structure |
| Solidago | molecule-mediator |
| Streptococcus | organism |
| TGF-beta | molecule-mediator |
| TGR5 | receptor-channel |
| Tight junctions | structure |
| Tissue transglutaminase | molecule-mediator |
| TLR4 | receptor-channel, process |
| Tregs | molecule-mediator, cell-type |
| Tryptophan | molecule-mediator, organism |
| TSLP | molecule-mediator |
| Ulcerative Colitis | clinical-concept, process |
| Vagus nerve | structure, intervention, diagnostic |
| visceral insular cortex | psychological, structure |
| Zein | clinical-concept |
| zinc carnosine | intervention, molecule-mediator |
| ZO-1 | intervention |
| Zonulin | diagnostic |
| α-hemolysin | organism, environmental |