Concepts linking metabolic processes to hormonal control -- insulin signalling, leptin resistance, thyroid-metabolism coupling, and the energy allocation systems that determine body composition. Endocrine disruption is inseparable from metabolic disease in cPNI.
| Concept | Categories |
|---|---|
| 11-β-hydroxysteroid dehydrogenase | molecule-mediator |
| 12,13-diHOME | system-axis, intervention, gene-protein |
| 5α-reductase | molecule-mediator |
| acanthosis nigricans | clinical-concept |
| ACE | molecule-mediator, process |
| ACE2 | receptor-channel, process |
| acetoacetate | molecule-mediator |
| ADH | molecule-mediator |
| adipocyte hypertrophy | process |
| Adipocytes | process, cell-type |
| adipogenesis | process |
| Adipokine | process |
| adiponectin | molecule-mediator |
| adipose tissue | process |
| adiposity | uncategorized |
| Aldosterone | molecule-mediator |
| Allostatic load | diagnostic |
| AMPs | -- |
| androstenedione | molecule-mediator, process |
| Ang 1-7 | molecule-mediator |
| Ang II | molecule-mediator |
| angiotensin | molecule-mediator |
| angiotensin 1-7 | molecule-mediator |
| angiotensin II | molecule-mediator |
| angiotensinogen | molecule-mediator |
| appetite | uncategorized |
| AVP | molecule-mediator |
| Batokin | receptor-channel, intervention |
| BCAAs | nutrient |
| beta-hydroxybutyrate | intervention, psychological |
| birth weight | nutrient |
| bonding system physiology and cognitive reserve | -- |
| bone metabolism | clinical-concept, nutrient |
| Bone-Muscle system | system-axis |
| brain metabolism | clinical-concept, psychological |
| breast cancer | process |
| Breastmilk | nutrient |
| brown adipose tissue | intervention |
| calcium metabolism | nutrient |
| calcium-d-glucarate | intervention |
| cephalic phase | molecule-mediator, nutrient |
| chronobiology | environmental |
| chrysin | nutrient |
| circadian biology | environmental |
| circadian rhythm | system-axis, intervention, gene-protein |
| circadian rhythms | system-axis, psychological |
| circadian-rhythm | system-axis, gene-protein, psychological |
| citrullination and molecular mimicry | uncategorized |
| cold exposure | process, intervention |
| Cortisol | molecule-mediator |
| cortisol excess | clinical-concept |
| Cytochrome P450 | molecule-mediator |
| cytotrophic factors | nutrient |
| depression chronic pain chronic fatigue — bonding system failure | -- |
| developmental origins of health and disease | process, framework, molecule-mediator |
| developmental programming | process |
| diabetes | clinical-concept, environmental |
| dihydrotestosterone | molecule-mediator |
| DIM | intervention |
| DIO3 | molecule-mediator, process |
| ectopic fat | process |
| edema | process |
| energy supply strategy | clinical-concept |
| erythropoietin | molecule-mediator |
| estrogen metabolism | molecule-mediator |
| estrogen-dominance | process |
| estrone | molecule-mediator |
| evolutionary buffers | uncategorized |
| fasting | process, intervention |
| fat oxidation | process |
| fatty acids | nutrient |
| fatty-acids | intervention |
| FGF21 | molecule-mediator |
| FOXO | gene-protein |
| Free fatty acids | process |
| free T4 | diagnostic |
| free-fatty-acids | intervention |
| gene transcription | process, gene-protein, nutrient |
| Ghrelin | molecule-mediator |
| GIP | molecule-mediator |
| GLP | molecule-mediator |
| GLP | molecule-mediator |
| GLP-1 | molecule-mediator |
| Glucagon | molecule-mediator |
| Gluconeogenesis | process, molecule-mediator, cell-type |
| glucose metabolism | structure, psychological |
| GLUT4 | receptor-channel |
| GLUT4 transporters | receptor-channel |
| glutathione peroxidase | molecule-mediator |
| glycerol | uncategorized |
| glycogenolysis | process |
| GPR109A | molecule-mediator, receptor-channel |
| Growth hormone | molecule-mediator |
| HbA1c | diagnostic |
| hippocampal bottleneck | -- |
| homeostatic | system-axis, psychological |
| hormone-sensitive lipase | molecule-mediator |
| HPS-axis | system-axis |
| HSL | molecule-mediator |
| hunter | clinical-concept, psychological |
| hunter-gatherer | clinical-concept |
| Hunter-Gatherer Metabolism | clinical-concept |
| Hunter-Gatherer Metabolism | nutrient |
| Hunter-Gatherer Phenotype | clinical-concept |
| hyperglycaemia | diagnostic |
| hyperinsulinaemia | process |
| hypermetabolism | cell-type, clinical-concept, nutrient |
| hypothyroid | clinical-concept, intervention, nutrient |
| hypothyroidism | clinical-concept, psychological |
| IGF-1 | receptor-channel, system-axis |
| IGF-1 receptor | receptor-channel |
| Insl6 | uncategorized |
| Insulin | molecule-mediator |
| insulin receptor | receptor-channel |
| insulin receptors | receptor-channel |
| insulin resilience | process, psychological |
| insulin resistance | process |
| insulin sensitivity | diagnostic, psychological |
| insulin signaling | system-axis |
| Iodine | nutrient, psychological |
| iodine deficiency | environmental |
| Irisin | gene-protein, intervention, psychological |
| JAK-STAT | gene-protein, receptor-channel, system-axis |
| L-DOPA | intervention, molecule-mediator |
| lateral hypothalamus | psychological |
| Leptin | molecule-mediator |
| LGI | clinical-concept, nutrient, environmental |
| lipedema | process |
| Lipolysis | process |
| MAS receptor | receptor-channel |
| Metabolic Depression | clinical-concept |
| Metabolic flexibility | nutrient, intervention, psychological |
| Metabolic programming | process, nutrient |
| metabolic syndrome | clinical-concept, process |
| metabolic-exhaustion | clinical-concept, process |
| metabolic-stability | nutrient |
| metabolic-stress | clinical-concept, psychological |
| metabolic-syndrome | clinical-concept, process |
| metabolic-system | system-axis |
| Metaflammation | process, nutrient |
| Metformin | uncategorized |
| microRNA | process |
| Mineralocorticoid Receptor | receptor-channel |
| mitochondrial-derived peptides | intervention, gene-protein |
| mitokines | molecule-mediator |
| MOTS-c | intervention, gene-protein |
| myxedema | clinical-concept |
| NAD | molecule-mediator, intervention, psychological |
| Nucleus Arcuatus | structure, diagnostic, nutrient |
| nucleus-arcuatus | nutrient |
| obesity | process |
| orexin | molecule-mediator |
| orexin pathway | system-axis |
| Orexins | molecule-mediator, psychological |
| osmolarity | psychological |
| Osteoblasts | cell-type, gene-protein, psychological |
| Osteocalcin | molecule-mediator |
| Osteocalcin | psychological |
| osteocalcin undercarboxylated | molecule-mediator |
| osteoporosis | process, nutrient, clinical-concept |
| Parathyroid hormone | molecule-mediator |
| PCOS | process |
| PKA | molecule-mediator, system-axis, receptor-channel |
| Pleiotropic antagonism | uncategorized |
| PPAR signaling | molecule-mediator, gene-protein |
| preeclampsia | clinical-concept, process |
| prostate cancer | environmental |
| RAA-system | system-axis, intervention |
| reactivation strategy | molecule-mediator, nutrient |
| reactivation strategy | intervention |
| renin | molecule-mediator |
| reverse T3 | process |
| Roxadustat | intervention |
| SAH | molecule-mediator |
| salt | clinical-concept |
| sarcopenia | intervention, diagnostic, environmental |
| Selective resistance | system-axis, organism |
| Selective resistance | clinical-concept |
| Selenium | nutrient, molecule-mediator |
| selenoprotein | molecule-mediator |
| Selfish Brain | framework, psychological |
| selfish-brain | clinical-concept, diagnostic, framework |
| sleep | process, psychological |
| sleep deprivation | process |
| sleep disorders | process, clinical-concept |
| sleep optimization | process, intervention |
| SOCS3 | system-axis, receptor-channel, clinical-concept |
| SOCS3 | receptor-channel, cell-type, clinical-concept |
| sodium | uncategorized |
| subclinical hypothyroidism | clinical-concept, psychological |
| thyroid dysfunction | clinical-concept, process |
| thyroid function | process |
| Type 1 diabetes | clinical-concept, intervention, diagnostic |
| Type 2 Diabetes | clinical-concept |
| Tyrosine | molecule-mediator |
| UCP1 | structure, intervention |
| visceral adipose tissue | process |
| Water-Land Transition | process |
| Zinc | nutrient, molecule-mediator |
| zinc deficiency | nutrient, clinical-concept, intervention |
| α-ketoglutarate | process |
| β-cell stress hypothesis | process, framework, cell-type |