Concepts connecting nervous system function to metabolic regulation -- the selfish brain, energy partitioning, hypothalamic nutrient sensing, and the metabolic cost of neural activity. Brain metabolism consumes 20% of resting energy, making this axis central to metabolic disease.
| Concept | Categories |
|---|---|
| 3-Hydroxykynurenine | process |
| 5-HTP | intervention |
| 5-MTHF | molecule-mediator |
| Acrocyanosis | process |
| ADH | molecule-mediator |
| AGEs | process |
| Akt | system-axis, gene-protein |
| alanine | molecule-mediator |
| alcohol | environmental, process |
| Allostatic load | diagnostic |
| Alzheimer's Disease | clinical-concept |
| AMPs | -- |
| Ang 1-7 | molecule-mediator |
| angiotensin 1-7 | molecule-mediator |
| anorexia | process |
| antioxidant defense | nutrient |
| appetite | uncategorized |
| arachidonic acid | molecule-mediator |
| aspartate | molecule-mediator |
| ataxia | -- |
| ATM gene | process, gene-protein |
| ATP | molecule-mediator |
| autoimmune disease | clinical-concept |
| Autoimmunity | clinical-concept |
| autophagy | intervention, nutrient |
| axon | receptor-channel, molecule-mediator |
| B vitamins | nutrient |
| B-complex | molecule-mediator |
| B-vitamins | molecule-mediator |
| B12 | molecule-mediator |
| beta-hydroxybutyrate | intervention, psychological |
| betaine | nutrient, molecule-mediator |
| BHMT | molecule-mediator |
| Biophotonic signalling | intervention, historical |
| BNIP3 | uncategorized |
| BNIP3L | intervention |
| bonding system physiology and cognitive reserve | -- |
| brain | structure |
| brain evolution | psychological, process |
| brain fog | psychological, process |
| brain function | psychological, molecule-mediator, process |
| brain health | clinical-concept, intervention, nutrient |
| brain metabolism | clinical-concept, psychological |
| brain size | structure, nutrient |
| breathwork | intervention |
| brown adipose tissue | intervention |
| Butyrate | molecule-mediator, process, intervention |
| caffeine | cell-type |
| Calcium | nutrient |
| caloric restriction | process |
| Ca²⁺ | system-axis, gene-protein |
| CB2 receptors | receptor-channel, process |
| cell membrane | system-axis, molecule-mediator |
| cell membranes | system-axis, intervention |
| Choline | nutrient |
| chronic inflammation | process, clinical-concept |
| chronic-fatigue | molecule-mediator |
| chronic-fatigue-syndrome | clinical-concept |
| chronic-inflammation | process, clinical-concept |
| chronobiology | environmental |
| chrysin | nutrient |
| circadian biology | environmental |
| circadian disruption | clinical-concept, environmental, process |
| circadian rhythm | system-axis, intervention, gene-protein |
| circadian rhythms | system-axis, psychological |
| circadian-rhythm | system-axis, gene-protein, psychological |
| Clathrin | uncategorized |
| cognitive decline | process, psychological |
| cognitive function | psychological, process |
| cognitive impairment | structure, nutrient, psychological |
| cold exposure | process, intervention |
| cold-exposure | intervention, process |
| Cortisol | molecule-mediator |
| COVID-19 | receptor-channel, intervention, psychological |
| COX2 | molecule-mediator, process |
| creatine phosphate | molecule-mediator, intervention, psychological |
| CYP1A2 | molecule-mediator |
| CYP2D6 | molecule-mediator, gene-protein |
| cystathionine beta-synthase | molecule-mediator |
| cytochrome c oxidase | molecule-mediator |
| Cytokine receptors | receptor-channel, system-axis |
| Cytokine resistance | intervention |
| Cytokine storm | clinical-concept |
| darapladib | intervention |
| dementia | process |
| Deprenyl | psychological |
| depression chronic pain chronic fatigue — bonding system failure | -- |
| Design limits | structure, intervention, historical |
| developmental programming | process |
| DHA | molecule-mediator |
| diet-induced neuropathy | molecule-mediator, process |
| DNA | gene-protein |
| DNA damage | process, nutrient, environmental |
| DNA methyltransferases | molecule-mediator, process, gene-protein |
| Docosahexaenoic Acid | molecule-mediator |
| dopamine system | psychological |
| dorsal root ganglia | structure |
| EGCG | molecule-mediator, nutrient |
| Ego depletion | process, intervention, psychological |
| eicosanoid | molecule-mediator, process |
| Eicosapentaenoic Acid | molecule-mediator |
| electron transport chain | uncategorized |
| electronic pollution and brainwave interference | -- |
| Endocannabinoid System | system-axis, molecule-mediator, cell-type |
| Endoplasmic Reticulum Stress | nutrient |
| endothelial dysfunction | process |
| Energy Distribution | process, psychological |
| energy metabolism | cell-type, nutrient |
| eNOS | molecule-mediator, intervention |
| environmental toxins | process, environmental |
| EPA | molecule-mediator |
| Epicatechins | nutrient, molecule-mediator |
| EPO | molecule-mediator |
| ERK | process, gene-protein |
| ERK1-2 | process, gene-protein |
| FFAR3 | receptor-channel |
| fluorodeoxyglucose positron emission tomography | diagnostic |
| folate | molecule-mediator |
| FOXO | gene-protein |
| FoxO1 | gene-protein |
| FPR1 | receptor-channel, process |
| free radicals | system-axis |
| gastroparesis | clinical-concept, process |
| gene expression | process |
| Glucose | cell-type, structure, psychological |
| glucose metabolism | structure, psychological |
| GLUT4 transporters | receptor-channel |
| glycine | molecule-mediator |
| GPR41 | receptor-channel |
| GSH | molecule-mediator |
| gut | structure |
| health governor | psychological |
| heart | structure |
| heart failure | clinical-concept, process |
| heart rate | diagnostic |
| heart rate variability | diagnostic |
| heat | receptor-channel, intervention, diagnostic |
| heat exposure | intervention, process |
| heat shock protein | process |
| Heat shock proteins | process |
| heat stress | process |
| heavy metals | environmental |
| hepatic encephalopathy | clinical-concept |
| HIF | gene-protein, process |
| HIF-1 | process, gene-protein |
| hippocampal bottleneck | -- |
| HITM-AMP | -- |
| homeostatic | system-axis, psychological |
| Homocysteine | molecule-mediator |
| HSR | uncategorized |
| Humanin | intervention, receptor-channel, system-axis |
| Hydroxytyrosol | molecule-mediator, nutrient |
| hypercapnia | intervention |
| hypermetabolism | cell-type, clinical-concept, nutrient |
| Hypothalamic Inflammation | process, cell-type, intervention |
| Hypothalamus inflammation | process, cell-type, structure |
| hypothyroidism | clinical-concept, psychological |
| hypoxia | psychological, gene-protein |
| Hypoxia stress response | gene-protein |
| Hypoxia-Inducible Factor | gene-protein |
| IDO | molecule-mediator |
| IL-1β | molecule-mediator |
| IL-6 | molecule-mediator, process |
| indoleamine 2,3-dioxygenase | molecule-mediator |
| inflammaging | clinical-concept, intervention |
| inflammation | process, cell-type, clinical-concept |
| inflammatory | process |
| inflammatory conditions | clinical-concept, process |
| infrared therapy | intervention |
| Insulin | molecule-mediator |
| insulin receptors | receptor-channel |
| insulin signaling | system-axis |
| Interleukin-6 | molecule-mediator, process |
| Intermittent fasting | process, intervention |
| introns | gene-protein, process |
| iodine deficiency | environmental |
| iron | nutrient |
| ischemia | uncategorized |
| JNK | process |
| KAT | molecule-mediator |
| KDM5A | process |
| ketogenesis | process, intervention, psychological |
| ketogenic diet | process, nutrient |
| ketogenic-diet | nutrient, intervention, psychological |
| KYNA | molecule-mediator |
| Kynurenic acid | molecule-mediator |
| L-DOPA | intervention, molecule-mediator |
| Lactate | molecule-mediator |
| lateral hypothalamus | psychological |
| LGI | clinical-concept, nutrient, environmental |
| Long COVID | intervention, psychological |
| Long-COVID | process |
| Luteolin | nutrient, molecule-mediator |
| lysophospholipids | molecule-mediator, process |
| Magnesium | nutrient |
| MCT transporters | receptor-channel |
| MCT-transporters | receptor-channel |
| MCT1 | receptor-channel |
| Metabolic Depression | clinical-concept |
| metabolic switching | cell-type |
| metabolic-dysfunction | clinical-concept, process, psychological |
| metabolic-stability | nutrient |
| metabolic-stress | clinical-concept, psychological |
| Methylation | process |
| micronutrient deficiencies | clinical-concept |
| micronutrient leverage model | psychological, framework, nutrient |
| microRNA | process |
| MIPS model | framework |
| miR-29 | process |
| mitochondria | structure |
| mitochondrial dysfunction | clinical-concept, process |
| Mitochondrial Information Processing System | system-axis, intervention, framework |
| mitohormesis | process |
| Mitophagy | process, intervention |
| mitoresilience | intervention, psychological |
| mobile internet block — Castelo 2025 | -- |
| monocarboxylate transporters | receptor-channel |
| morphine production | process, cell-type, intervention |
| movement | cell-type, intervention |
| mtDNA | gene-protein |
| MTHFR | molecule-mediator, gene-protein |
| MXI1 | gene-protein |
| myelination | process |
| NAD | molecule-mediator, intervention, psychological |
| neurodegeneration | clinical-concept, process |
| Neuroprotectins | molecule-mediator |
| Neuroprotectins | molecule-mediator, process |
| neurotransmitter synthesis | process, nutrient, psychological |
| NF-kB | gene-protein, process |
| niacin | molecule-mediator |
| Nicotinamide | molecule-mediator |
| Nitric Oxide | process |
| Non-Canonical HIF Regulation | process, intervention, gene-protein |
| Nucleus Arcuatus | structure, diagnostic, nutrient |
| nucleus-arcuatus | nutrient |
| nutrient deficiencies | nutrient, psychological |
| nutrients | nutrient |
| orexin | molecule-mediator |
| orexin pathway | system-axis |
| Orexins | molecule-mediator, psychological |
| osmolarity | psychological |
| oxidative damage | process |
| Parasympathetic | molecule-mediator |
| parasympathetic nervous system | molecule-mediator, system-axis |
| Parkinson's Disease | process, clinical-concept, molecule-mediator |
| pattern recognition receptors | cell-type |
| peroxynitrite | process |
| PGC-1alpha | gene-protein, intervention |
| PGE2 | molecule-mediator, process |
| PHD Inhibitors | intervention |
| phenylalanine | molecule-mediator |
| phosphatidylserine | molecule-mediator, system-axis, intervention |
| phospholipase A2 | molecule-mediator, process |
| photobiomodulation | intervention, process |
| physical activity | intervention, process |
| PKA | molecule-mediator, system-axis, receptor-channel |
| PKA | molecule-mediator, system-axis, receptor-channel |
| PKC | molecule-mediator, system-axis, receptor-channel |
| PLA2G7 | molecule-mediator |
| PLA2G7 | molecule-mediator |
| pollution | environmental, process |
| Post-translational modification | process |
| potassium | nutrient |
| pronociceptive metabolites | molecule-mediator, process |
| Protectins | molecule-mediator |
| protein folding | process, environmental |
| protein synthesis | process, system-axis |
| reactivation strategy | molecule-mediator, nutrient |
| Reactive Oxygen Species | system-axis |
| resveratrol | intervention, nutrient, molecule-mediator |
| riboflavin | molecule-mediator, intervention |
| RNA Metabolism | process, clinical-concept |
| Rosemary | psychological |
| Rutin | molecule-mediator, nutrient |
| RvD1 | molecule-mediator |
| Sage | molecule-mediator |
| SAH | molecule-mediator |
| SAM-e | molecule-mediator, intervention |
| sauna | process, intervention, environmental |
| Selfish Brain | framework, psychological |
| Selfish brain theory | framework, psychological |
| selfish-brain | clinical-concept, diagnostic, framework |
| selfish-immune-system | process, system-axis |
| serine | molecule-mediator |
| SHLP1-6 | system-axis, intervention |
| SHMT2 | molecule-mediator |
| sialylation | process, intervention |
| single nucleotide polymorphisms | gene-protein |
| sleep | process, psychological |
| sleep deprivation | process |
| sleep disorders | process, clinical-concept |
| sleep optimization | process, intervention |
| smoking | process, clinical-concept |
| sodium | uncategorized |
| stroke | clinical-concept |
| sympathetic dominance | clinical-concept |
| sympathetic tone | diagnostic |
| synaptic-plasticity | psychological, process |
| systemic inflammation | process, clinical-concept, diagnostic |
| TDO | molecule-mediator |
| Therapeutic hypercapnia | intervention, process |
| thermoregulation | process, psychological |
| time-restricted eating | intervention |
| Transferrins | process, nutrient |
| Transketolase | molecule-mediator |
| TRP channels | receptor-channel, cell-type, intervention |
| TRPA1 | receptor-channel |
| TRPV1 | receptor-channel |
| tumor necrosis factor | molecule-mediator |
| Tyrosine | molecule-mediator |
| vasoconstriction | process, receptor-channel, nutrient |
| Vasoconstriction Mechanism | uncategorized |
| vasodilation | process |
| Vitamin B1 | nutrient, clinical-concept, intervention |
| Vitamin B12 | nutrient |
| Vitamin B6 | nutrient, molecule-mediator, intervention |
| White Matter Integrity | structure, psychological |
| β-hydroxybutyrate | molecule-mediator, intervention |